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Weissman’s team is working on a different approach to dealing with old human blood stem cells. It will be at least 3 to 5 years before they can begin testing it in people, he says.

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In the meantime, his team will continue to study mice to learn more about other effects of the antibody therapy, such as whether it affects the rates of cancer or inflammatory diseases. “The old versus the young blood-forming system makes a big deal of difference,” says Weissman. “It’s not just a difference in the bone marrow. It is a difference all over the body.

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Clonal analysis of hematopoietic stem cell differentiation in vivo and its connection with the immune privilege in human bone marrow

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Source: Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

High-dimensional single-cell cytometry in a study of neogenin-1 stimulates aneurysm formation in the abdominal aortic region

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Source: Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

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Source: Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

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