There is a functional evaluation and clinical classification of the BRCA 2 variant
A study has revealed that a deep learning model could predict genome-wide variant effects using deep learning-derived scores. The model was developed using ACMG/AMP scoring rules for clinical classification of the BRCA2 SNVs. It predicted variant effects based on gene expression analysis and found that variants in the BRCA1 or BRCA2 are associated with breast, ovarian, pancreatic, and prostate cancer tumours.
There is a model for human cell types
A model for a single-cell accessibility dataset was developed to predict expression in various cell types, including astrocytes. The model was trained on the fetal accessibility and expression atlas. To identify accessible regions specific to each cell type, peak calling results from the original studies of each dataset were used to obtain a union set of peaks.
Despite the rosy predictions, embryo editing against disease is unsafe and has no proven success
Polygenic genome editing in human embryos can reduce the chances of certain diseases, but it raises new concerns of the threat of eugenics, according to a study published in the journal Nature Biotechnology. The researchers found that in some cases, editing a single variant associated with a polygenic disease can have strong effects. edit up to ten genes associated with a disease can reduce its lifetime prevalence.
The partners say that they were blindsided by the Decision to Axe Them
Facebook’s Meta fact-checking platform is terminating its partnership with Poynter Institute and the International Fact-Checking Network. The Poynter Institute and the International Fact-Checking Network are among the fact-checking partners on Meta. Notably, the Poynter Institute also operates PolitiFact, which is an Meta fact-checking partner. Meta said the move was due to it making “too many mistakes”.
The emergence of quantum mechanics a century ago
Lucy Mensing, a founding member of the ‘Interdisciplinary Group on Heligoland’, worked out some of the first applications of his quantum-mechanical theory in the 1970s, Daniela Monaldi, a historian at York University in Toronto, Canada said. Heisenberg had developed a theory of motion in which electrons could no longer be thought of as particles that move along continuous trajectories.
Police say the man who blew up Cybertruck in Las Vegas used a planning tool
Matthew Livelsberger, the US soldier who blew up a Tesla Cybertruck in Las Vegas on New Year’s Day, used generative AI including ChatGPT to help plan the attack, Las Vegas police said. Livelsberger left notes saying that the explosion was a stunt meant to be a “wake up call” for the nation’s troubles, officials said last week.
Meta will end fact checking as the Silicon Valley prepares for Trump
Facebook’s third-party fact-checking tool Meta has decided to end its partnership with the platform. It will rely on a community notes program which it said would allow users to write and rate notes next to posts, instead of automated systems. Meta CEO Alexios Mantzarlis said that Meta has made “too many mistakes” in how it applied its content policies.
As of this April, you will be able to install SteamOS on other handhelds
Lenovo has announced that its Legion Go S handheld will ship with Microsoft’s Windows 10 operating system this month, four months ahead of the SteamOS versions. The 16-inch Legion Go S device ditches the Nintendo Switch-like detachablegamepads and kickstand for a lighter and more traditional design. It will have a 1.6-pound weight and will be available in white or black colours.
The Z2 is not coming to a steam deck near you, it is an official chip
Lenovo will be launching a Windows version of its Legion Go S handheld, four months ahead of the Windows versions of its SteamOS devices. It will be shipping the Windows version this month, four months ahead of SteamOS models. It’ll also be one of the few handhelds that will offer a 120Hz variable refresh rate screen.
Is this the best time to invest incryptocurrencies in the foreseeable future?
The US President Donald Trump has said that the country will start a “strategic national stockpile” made up of Bitcoins. The US could buy up to 2,00,000 Bitcoins a year for five years, until they reach 10,00,000, he added. This plan comes after US Securities and Exchange Commission (SEC) approved investment funds to track the price of Bitcoin.