How to kill Escherichia coli using ribosome-targeted antibiotics: Insights from a lab technician’s garden

The latest molecule targets bacteria’s protein-making factory, the ribosome, in a way that other antibiotic drugs don’t. The ribosome is an attractive target for antibiotics because there are no antibiotics that can cause resistance to the structure.

The soil samples were collected from a lab technician’s garden. Kim Lewis, a microbiologist at Northeastern University in Boston, Massachusetts who was not involved with the research, says there is terrifically interesting stuff hidden in plain sight. “Kudos to them that they knew what to look for.”

The search for new antibiotics is necessary because bacteria acquire resistance to existing drugs with continued use. In 2021, bacterial resistance to antimicrobial drugs was associated with 1.1 million deaths globally, a figure that could increase to 1.9 million by 2050.

Wright and his group were looking for the microbes that had developed tricks to kill diseases. They collected soil samples in Petri dishes with growth medium and stored them for a year. The researchers then exposed the microbes from these samples to Escherichia coli, a common gut bacterium that can cause serious disease.

Further rounds of screening and analysis have revealed that the bacterium produces a molecule that forms a lasso-shaped knot. The robust nature of these peptides makes them able to survive being swallowed. “It’s a nice, really compact and incredibly robust structure,” says Wright.

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Source: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

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Source: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

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