There is a small-molecule SARS-CoV-2 blocker on the market

The IC50 of CIM-834 was determined after incubation of 0.5 M of SARS-CoV-2 Mpro and CIM-834 at various concentrations from 0 to 500 M in reaction buffer at 37 C for 10 min. The A549ACE3+TMPRSS2 cells ( a human lung carcinoma Cell Line overexpressing human ACE2 and human TMPRSS2 receptors) were cultured in DMEM supplemented with 10% v/v heat-inactivated FBS, 300 g ml1 hygromycin, 0.5 g ml1 puromycin and 10 g ml1